An interaction database for Escherichia coli


Bacteriome.org

Bacteriome.org is a database integrating physical (protein-protein) and functional interactions within the context of an E. coli knowledgebase. Presently the resource offers access to two types of network:
  • A network of functional interactions derived through exploiting available functional genomic datasets within a Bayesian framework
  • Two networks of experimentally derived protein-protein interactions - a 'core' network consisting of interactions deemed to be of 'high quality'; and an 'extended' network which extends the 'core' network by including interactions for which experimental evidence is less strong.

    • These datasets may be searched directly using the keyword search box below, or by the different search methods found on the left sidebar under Search Methods. Help on the different search methods are found on the Help pages     		Project Detail

    A key feature of the biological organization in all organisms is the tendency of proteins that function in common pathways to physically associate via stable protein-protein interactions (PPI) to form larger macromolecular assemblies or complexes (sometimes known as molecular machines). These complexes are often linked together by extended networks of weaker, transient PPI, to form extended networks or neighbourhoods that integrate pathways mediating the major cellular processes..... (more information)
    Keyword Search For Genes/Proteins:

    The keyword can range from gene names (e.g. 'clpX'), to protein domains (e.g. 'PF07724' or 'P-loop containing') and functional categories (e.g. 'kinase' or 'translocase'). It can be a whole word, part of a word, or a combination of words. The search is case in-sensitive


    e.g. clpX or kinase