Understanding Biological Complexity

Please visit our new site at compsysbio.org.

Our research can be classified into five overlapping themes:

  • Computational simulations - Our lab has created a series of 3D computer models to simulate cellular processes such as metabolism and lipid raft mediated signalling.
  • Comparative genomics - We use partial and complete genome sequences to explore sequence diversity and the evolution of biological pathways and complexes.
  • The Extracellular Matrix - The extracellular matrix provides multicellular organisms with their basic biological form, we are interested in understanding how the matrix evolved and how it is organized to provide fundamental mechanical properties.
  • Network Biology - In collaboration with other researchers in Toronto, we are interested in examining the structure and function of biological networks such as physical protein-protein interactions.
  • Parasites - The apicomplexa are a group of related protist parasites that include Plasmodium and Toxoplasma - the causative agents of malaria and toxoplasmosis. In collaboration with Dr Michael Grigg at the NIH, our lab combines network biology with comparative genomics to identify genes that are critical to the survivial of toxoplasma within the human host.