Gene Details


gene name: nagC


locus tag k12ECK0664 Crenarchaeota Euryarchaeota Nanoarcheota Alphaproteobacteria Betaproteobacteria Gammaproteobacteria Deltaproteobacteria Epsilonproteobacteria Cyanobacteria Actinobacteridae Firmicutes Spirochaetes others Protist Microsporidia Fungi Metazoa Plantae
information on phylogenetic profile
locus tag mg1655b0676
locus tag w3110JW0662
gene name k12nagC
locus namenagC
synonyms of locus namenagR

scop id46785; 53067
superfamilyWinged helix; Actin-like ATPase domain
pfam idPF00480
pfam domainROK family
TIGRFAMno information

swissprot nameNAGC_ECOLI
descriptionN-acetylglucosamine repressor.
seq length406
fastaseq

go idGO:0005737; GO:0016563; GO:0016564; GO:0006350; GO:0046349; GO:0009386
go termcytoplasm; transcriptional activator activity; transcriptional repressor activity; transcription; amino sugar biosynthesis; translational attenuation

gene product descriptionDNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine
comment gene product description
evidenceE
context
gene product descRegulator
cell locationCytoplasmic
featuresCDS

functional category codeK; G
functional categoryTranscription ; Carbohydrate transport and metabolism

reference #1Expression of the chitobiose operon of Escherichia coli is regulated by three transcription factors: NagC, ChbR and CAP.

Plumbridge J., Pellegrini O. (Mol Microbiol. 2004 Apr; 52(2):437-49)
reference #2Analysis of the nag regulon from Escherichia coli K12 and Klebsiella pneumoniae and of its regulation.

Vogler A., Lengeler J. (Mol Gen Genet. 1989 Oct; 219(1-2):97-105)
reference #3CAP and Nag repressor binding to the regulatory regions of the nagE-B and manX genes of Escherichia coli.

Plumbridge J., Kolb A. (J Mol Biol. 1991 Feb 20; 217(4):661-79)
reference #4Repression and induction of the nag regulon of Escherichia coli K-12: the roles of nagC and nagA in maintenance of the uninduced state.

Plumbridge J. (Mol Microbiol. 1991 Aug; 5(8):2053-62)
reference #5A dominant mutation in the gene for the Nag repressor of Escherichia coli that renders the nag regulon uninducible.

Plumbridge J. (J Gen Microbiol. 1992 May; 138(5):1011-7)
reference #6Cloning and characterization of the N-acetylglucosamine operon of Escherichia coli.

Peri K., Goldie H., Waygood E. (Biochem Cell Biol. 1990 Jan; 68(1):123-37)
reference #7Sequence of the nagBACD operon in Escherichia coli K12 and pattern of transcription within the nag regulon.

Plumbridge J. (Mol Microbiol. 1989 Apr; 3(4):505-15)
reference #8Co-ordinated regulation of amino sugar biosynthesis and degradation: the NagC repressor acts as both an activator and a repressor for the transcription of the glmUS operon and requires two separated NagC binding sites.

Plumbridge J. (EMBO J. 1995 Aug 15; 14(16):3958-65)

phylogenetic profile
 
77 65 1 1 1 71 1 1 1 1 1 1 119 1 1 1 113 114 1 153
120 104 122 116 85 1 85 85 115 120 163 169 198 77 77 110 1 1 105 125
124 71 126 1 1 1 1 132 1 1 1 1 1 54 85 1 1 1 1 116
109 1 91 1 94 93 95 1 1 1 119 1 1 1 1 1 125 125 149 215
198 137 114 144 134 113 56 112 103 155 157 158 157 159 1 1 52 1 73 65
1 61 166 1 103 103 103 103 103 114 114 113 105 105 117 117 117 117 117 175
1 1 1 1 1 1 1 602 797 797 797 70 1 1 109 68 432 610 1 1
77 753 751 753 81 797 797 484 484 480 1 50 61 1 1 635 634 634 82 149
152 1 1 1 1 1 1 84 97 115 107 73 1 130 108 71 89 1 1 89
1 1 1 1 1 1 1 1 1 1 1 1 86 85 1 1 1 1 1