gene name: hslV
| locus tag k12 | ECK3924 | information on phylogenetic profile |
|---|---|---|
| locus tag mg1655 | b3932 | |
| locus tag w3110 | JW3903 | |
| gene name k12 | hslV | |
| locus name | hslV | |
| synonyms of locus name | htpO, clpQ, yiiC |
| scop id | 56235 |
|---|---|
| superfamily | N-terminal nucleophile aminohydrolases (Ntn hydrolases) |
| pfam id | PF00227 |
| pfam domain | Proteasome A-type and B-type |
| TIGRFAM | no information |
| swissprot name | HSLV_ECOLI |
|---|---|
| description | ATP-dependent protease hslV (EC 3.4.25.-) (Heat shock protein hslV). |
| seq length | 175 |
| fastaseq |
| go id | GO:0005737; GO:0008233; GO:0006457; GO:0006508 |
|---|---|
| go term | cytoplasm; peptidase activity; protein folding; proteolysis and peptidolysis |
| gene product description | peptidase component of the HslUV protease |
|---|---|
| comment gene product description | |
| evidence | E |
| context | |
| gene product desc | Enzyme |
| cell location | Cytoplasmic |
| features | CDS |
| functional category code | O |
|---|---|
| functional category | Posttranslational modification, protein turnover, chaperones |
| reference #1 | The ATP-dependent HslVU/ClpQY protease participates in turnover of cell division inhibitor SulA in Escherichia coli. Kanemori M., Yanagi H., Yura T. (J Bacteriol. 1999 Jun; 181(12):3674-80) |
|---|---|
| reference #2 | Identification and characterization of HsIV HsIU (ClpQ ClpY) proteins involved in overall proteolysis of misfolded proteins in Escherichia coli. Missiakas D., Schwager F., Betton J., Georgopoulos C., Raina S. (EMBO J. 1996 Dec 16; 15(24):6899-909) |
| reference #3 | ATP-dependent degradation of SulA, a cell division inhibitor, by the HslVU protease in Escherichia coli. Seong I., Oh J., Yoo S., Seol J., Chung C. (FEBS Lett. 1999 Jul 30; 456(1):211-4) |
| reference #4 | The structures of HsIU and the ATP-dependent protease HsIU-HsIV. Bochtler M., Hartmann C., Song H., Bourenkov G., Bartunik H., Huber R. (Nature. 2000 Feb 17; 403(6771):800-5) |
| reference #5 | Sequence analysis of four new heat-shock genes constituting the hslTS/ibpAB and hslVU operons in Escherichia coli. Chuang S., Burland V., Plunkett G., Daniels D., Blattner F. (Gene. 1993 Nov 30; 134(1):1-6) |
| reference #6 | Molecular cloning of a novel gene involved in serotonin receptor-mediated signal transduction in rat stomach. Ohya S., Takii T., Yamazaki H., Matsumori M., Onozaki K., Watanabe M., Imaizumi Y. (FEBS Lett. 1997 Jan 20; 401(2-3):252-8) |
| reference #7 | Crystal structure of heat shock locus V (HslV) from Escherichia coli. Bochtler M., Ditzel L., Groll M., Huber R. (Proc Natl Acad Sci U S A. 1997 Jun 10; 94(12):6070-4) |
| reference #8 | Mutagenesis of two N-terminal Thr and five Ser residues in HslV, the proteolytic component of the ATP-dependent HslVU protease. Yoo S., Shim Y., Seong I., Seol J., Kang M., Chung C. (FEBS Lett. 1997 Jul 21; 412(1):57-60) |
| phylogenetic profile |
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