Gene Details


gene name: fmt


locus tag k12ECK3274 Crenarchaeota Euryarchaeota Nanoarcheota Alphaproteobacteria Betaproteobacteria Gammaproteobacteria Deltaproteobacteria Epsilonproteobacteria Cyanobacteria Actinobacteridae Firmicutes Spirochaetes others Protist Microsporidia Fungi Metazoa Plantae
information on phylogenetic profile
locus tag mg1655b3288
locus tag w3110JW3249
gene name k12fmt
locus namefmt
synonyms of locus nameyhdD, ftm

scop id53328; 50486
superfamilyFormyltransferase; FMT C-terminal domain-like
pfam idPF00551; PF02911
pfam domainFormyl transferase; Formyl transferase, C-terminal domain
tigrfam idTIGR00460
namefmt
functionmethionyl-tRNA formyltransferase

swissprot nameFMT_ECOLI
descriptionMethionyl-tRNA formyltransferase (EC 2.1.2.9).
seq length314
fastaseq

go idGO:0005737; GO:0009451
go termcytoplasm; RNA modification

gene product description10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase
comment gene product description
evidenceE
context
gene product descEnzyme
cell locationCytoplasmic
featuresCDS

functional category codeJ
functional categoryTranslation, ribosomal structure and biogenesis

reference #1Structural and sequence elements important for recognition of Escherichia coli formylmethionine tRNA by methionyl-tRNA transformylase are clustered in the acceptor stem.

Lee C., Seong B., RajBhandary U. (J Biol Chem. 1991 Sep 25; 266(27):18012-7)
reference #2Disruption of the gene for Met-tRNA(fMet) formyltransferase severely impairs growth of Escherichia coli.

Guillon J., Mechulam Y., Schmitter J., Blanquet S., Fayat G. (J Bacteriol. 1992 Jul; 174(13):4294-301)
reference #3The Escherichia coli fmt gene, encoding methionyl-tRNA(fMet) formyltransferase, escapes metabolic control.

Meinnel T., Guillon J., Mechulam Y., Blanquet S. (J Bacteriol. 1993 Feb; 175(4):993-1000)
reference #4Disruption of the gene for Met-tRNA(fMet) formyltransferase severely impairs growth of Escherichia coli.

Guillon J., Mechulam Y., Schmitter J., Blanquet S., Fayat G. (J Bacteriol. 1992 Jul; 174(13):4294-301)
reference #5Nucleotide sequence of the rpoA-rplQ DNA of Escherichia coli: a second regulatory binding site for protein S4?

Meek D., Hayward R. (Nucleic Acids Res. 1984 Jul 25; 12(14):5813-21)
reference #6The Escherichia coli fmt gene, encoding methionyl-tRNA(fMet) formyltransferase, escapes metabolic control.

Meinnel T., Guillon J., Mechulam Y., Blanquet S. (J Bacteriol. 1993 Feb; 175(4):993-1000)
reference #7Structure of crystalline Escherichia coli methionyl-tRNA(f)Met formyltransferase: comparison with glycinamide ribonucleotide formyltransferase.

Schmitt E., Blanquet S., Mechulam Y. (EMBO J. 1996 Sep 2; 15(17):4749-58)
reference #8A survey of polypeptide deformylase function throughout the eubacterial lineage.

Mazel D., Coïc E., Blanchard S., Saurin W., Marlière P. (J Mol Biol. 1997 Mar 14; 266(5):939-49)
reference #9Crystal structure of methionyl-tRNAfMet transformylase complexed with the initiator formyl-methionyl-tRNAfMet.

Schmitt E., Panvert M., Blanquet S., Mechulam Y. (EMBO J. 1998 Dec 1; 17(23):6819-26)

phylogenetic profile
 
1 1 1 1 1 1 1 1 1 1 54 52 1 1 1 1 1 1 1 209
205 199 211 189 180 175 180 179 216 200 218 217 269 145 144 232 249 248 235 258
258 237 231 234 219 216 208 228 192 306 274 306 278 278 305 290 290 283 288 204
232 179 169 177 173 218 231 235 292 249 263 181 120 163 165 166 253 249 183 250
263 261 227 249 243 238 233 219 210 246 240 241 235 240 115 110 1 154 190 190
135 152 238 1 233 233 233 233 233 221 221 224 223 222 220 221 220 219 219 253
136 313 255 264 275 280 338 488 614 624 623 395 314 318 397 333 383 480 368 360
353 582 583 582 418 623 623 411 405 394 275 298 298 290 293 494 496 496 219 226
222 210 210 210 209 210 209 184 186 222 236 191 206 217 215 161 187 169 178 124
75 87 79 66 84 66 72 100 107 108 108 106 127 130 1 139 129 1 50