Gene Details


gene name: thrC


locus tag k12ECK0004 Crenarchaeota Euryarchaeota Nanoarcheota Alphaproteobacteria Betaproteobacteria Gammaproteobacteria Deltaproteobacteria Epsilonproteobacteria Cyanobacteria Actinobacteridae Firmicutes Spirochaetes others Protist Microsporidia Fungi Metazoa Plantae
information on phylogenetic profile
locus tag mg1655b0004
locus tag w3110JW0003
gene name k12thrC
locus namethrC
synonyms of locus name

scop id53686
superfamilyTryptophan synthase beta subunit-like PLP-dependent enzymes
pfam idPF00291
pfam domainPyridoxal-phosphate dependent enzyme
tigrfam idTIGR00260
namethrC
functionthreonine synthase

swissprot nameTHRC_ECOLI
descriptionThreonine synthase (EC 4.2.3.1).
seq length428
fastaseq

go idGO:0005737; GO:0009088
go termcytoplasm; threonine biosynthesis

gene product descriptionthreonine synthase
comment gene product description
evidenceE
context
gene product descEnzyme
cell locationCytoplasmic
featuresCDS

functional category codeE
functional categoryAmino acid transport and metabolism

reference #1Nucleotide sequence of thrC and of the transcription termination region of the threonine operon in Escherichia coli K12.

Parsot C., Cossart P., Saint-Girons I., Cohen G. (Nucleic Acids Res. 1983 Nov 11; 11(21):7331-45)
reference #2Threonine synthase of Escherichia coli: inhibition by classical and slow-binding analogues of homoserine phosphate.

Farrington G., Kumar A., Shames S., Ewaskiewicz J., Ash D., Wedler F. (Arch Biochem Biophys. 1993 Nov 15; 307(1):165-74)
reference #3Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.

Link A., Robison K., Church G. (Electrophoresis. 1997 Aug; 18(8):1259-313)
reference #4Protein identification with N and C-terminal sequence tags in proteome projects.

Wilkins M., Gasteiger E., Tonella L., Ou K., Tyler M., Sanchez J., Gooley A., Walsh B., Bairoch A., Appel R., Williams K., Hochstrasser D. (J Mol Biol. 1998 May 8; 278(3):599-608)
reference #5PROSITE: a dictionary of sites and patterns in proteins.

Bairoch A.
reference #6Interaction of aspartate and aspartate-derived antimetabolites with the enzymes of the threonine biosynthetic pathway of Escherichia coli.

Shames S., Ash D., Wedler F., Villafranca J. (J Biol Chem. 1984 Dec 25; 259(24):15331-9)

phylogenetic profile
 
1 1 1 1 1 1 1 1 1 1 57 58 1 60 68 65 1 1 1 175
169 174 177 180 54 57 54 54 1 1 1 1 1 1 1 205 220 1 216 229
231 236 233 210 1 1 1 209 1 192 192 192 174 174 189 173 179 192 175 1
1 1 1 1 1 54 1 1 207 66 222 150 165 135 137 145 55 53 53 59
64 65 159 1 172 1 1 166 181 1 1 1 1 1 1 1 1 1 1 1
1 1 53 1 60 60 60 60 60 169 166 177 171 170 1 1 1 1 1 56
1 53 493 529 537 537 1 662 815 816 816 549 217 217 558 1 555 663 221 224
228 763 763 763 462 810 811 557 548 549 1 252 254 258 256 683 683 683 1 339
343 1 1 1 1 1 1 320 182 1 1 73 1 1 1 1 81 178 1 81
201 205 202 208 183 199 189 209 220 1 1 1 1 145 1 72 64 1 1