Gene Details


gene name: rluA


locus tag k12ECK0059 Crenarchaeota Euryarchaeota Nanoarcheota Alphaproteobacteria Betaproteobacteria Gammaproteobacteria Deltaproteobacteria Epsilonproteobacteria Cyanobacteria Actinobacteridae Firmicutes Spirochaetes others Protist Microsporidia Fungi Metazoa Plantae
information on phylogenetic profile
locus tag mg1655b0058
locus tag w3110JW0057
gene name k12rluA
locus namerluA
synonyms of locus nameyabO

SCOPno information
pfam idPF00849
pfam domainRNA pseudouridylate synthase
TIGRFAMno information

swissprot nameRLUA_ECOLI
descriptionRibosomal large subunit pseudouridine synthase A (EC 5.4.99.-) (rRNA-|uridine isomerase A) (rRNA pseudouridylate synthase A).
seq length218
fastaseq

go idGO:0009451
go termRNA modification

gene product descriptionpseudouridine synthase for 23S rRNA (position 746) and tRNAphe(position 32)
comment gene product description
evidenceE
context
gene product descEnzyme
cell locationCytoplasmic
featuresCDS

functional category codeJ
functional categoryTranslation, ribosomal structure and biogenesis

reference #1Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA.

Raychaudhuri S., Niu L., Conrad J., Lane B., Ofengand J. (J Biol Chem. 1999 Jul 2; 274(27):18880-6)
reference #2Role of cysteine residues in pseudouridine synthases of different families.

Ramamurthy V., Swann S., Spedaliere C., Mueller E. (Biochemistry. 1999 Oct 5; 38(40):13106-11)
reference #3Functional importance of motif I of pseudouridine synthases: mutagenesis of aligned lysine and proline residues.

Spedaliere C., Hamilton C., Mueller E. (Biochemistry. 2000 Aug 8; 39(31):9459-65)
reference #4A dual-specificity pseudouridine synthase: an Escherichia coli synthase purified and cloned on the basis of its specificity for psi 746 in 23S RNA is also specific for psi 32 in tRNA(phe).

Wrzesinski J., Nurse K., Bakin A., Lane B., Ofengand J. (RNA. 1995 Jun; 1(4):437-48)
reference #5A frequently amplified region in Leishmania contains a gene conserved in prokaryotes and eukaryotes.

Myler P., Venkataraman G., Lodes M., Stuart K. (Gene. 1994 Oct 21; 148(2):187-93)

phylogenetic profile
 
1 1 1 1 1 1 1 1 89 1 1 1 1 1 1 1 1 1 1 90
110 114 110 119 105 95 105 105 107 112 112 106 104 106 106 222 112 107 105 117
117 122 100 108 102 102 105 113 111 92 92 92 130 129 216 114 114 127 121 150
110 101 114 107 108 111 99 92 151 119 102 84 78 71 78 90 1 112 112 97
107 105 103 104 103 1 105 112 111 110 109 109 109 109 79 102 83 68 100 85
104 87 105 87 94 91 94 91 94 109 110 109 108 107 109 110 109 109 109 110
86 194 108 108 108 114 1 352 451 447 447 283 94 100 289 179 280 337 206 212
1 433 434 433 276 388 451 233 256 251 92 104 108 108 110 330 330 330 99 154
164 92 92 92 94 86 1 107 110 81 103 102 1 135 108 109 84 90 94 84
101 104 88 93 77 95 87 86 91 1 72 85 97 105 72 92 87 1 74