Gene Details


gene name: nhaR


locus tag k12ECK0021 Crenarchaeota Euryarchaeota Nanoarcheota Alphaproteobacteria Betaproteobacteria Gammaproteobacteria Deltaproteobacteria Epsilonproteobacteria Cyanobacteria Actinobacteridae Firmicutes Spirochaetes others Protist Microsporidia Fungi Metazoa Plantae
information on phylogenetic profile
locus tag mg1655b0020
locus tag w3110JW0019
gene name k12nhaR
locus namenhaR
synonyms of locus nameyaaB, antO

SCOPno information
pfam idPF00126
pfam domainBacterial regulatory helix-turn-helix protei
TIGRFAMno information

swissprot nameNHAR_ECOLI
descriptionTranscriptional activator protein nhaR (Na+/H+ antiporter regulatory|protein).
seq length301
fastaseq

go idGO:0005737; GO:0016563; GO:0006350; GO:0009268
go termcytoplasm; transcriptional activator activity; transcription; response to pH

gene product descriptionDNA-binding transcriptional activator
comment gene product description
evidenceE
context
gene product descRegulator
cell locationCytoplasmic
featuresCDS

functional category codeK
functional categoryTranscription

reference #1NhaR, a protein homologous to a family of bacterial regulatory proteins (LysR), regulates nhaA, the sodium proton antiporter gene in Escherichia coli.

Rahav-Manor O., Carmel O., Karpel R., Taglicht D., Glaser G., Schuldiner S., Padan E. (J Biol Chem. 1992 May 25; 267(15):10433-8)
reference #2Na+/H+ antiporters, molecular devices that couple the Na+ and H+ circulation in cells.

Padan E., Schuldiner S. (J Bioenerg Biomembr. 1993 Dec; 25(6):647-69)
reference #3Structure of the DNA distal to the gene for ribosomal protein S20 in Escherichia coli K12: presence of a strong terminator and an IS1 element.

Mackie G. (Nucleic Acids Res. 1986 Sep 11; 14(17):6965-81)
reference #4A large family of bacterial activator proteins.

Henikoff S., Haughn G., Calvo J., Wallace J. (Proc Natl Acad Sci U S A. 1988 Sep; 85(18):6602-6)
reference #5A single amino acid substitution (Glu134-->Ala) in NhaR1 increases the inducibility by Na+ of the product of nhaA, a Na+/H+ antiporter gene in Escherichia coli.

Carmel O., Dover N., Rahav-Manor O., Dibrov P., Kirsch D., Karpel R., Schuldiner S., Padan E. (EMBO J. 1994 Apr 15; 13(8):1981-9)

phylogenetic profile
 
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 51
1 53 1 1 1 1 1 1 1 1 1 1 62 1 1 58 1 1 57 62
64 1 66 101 1 1 1 70 1 66 65 53 1 144 181 1 1 1 52 1
1 1 1 1 1 1 1 128 213 1 1 1 1 1 1 1 52 52 55 55
52 50 54 1 57 51 52 54 57 52 53 53 53 53 1 1 1 1 1 1
1 1 56 1 52 52 53 1 53 1 1 1 1 1 1 1 1 1 1 59
1 57 1 1 1 1 1 483 577 608 608 1 1 1 59 1 1 487 64 210
214 560 560 560 348 609 606 380 382 379 1 97 51 1 1 484 484 484 52 1
1 1 1 1 1 1 1 1 1 57 1 1 1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1