Gene Details


gene name: mprA


locus tag k12ECK2678 Crenarchaeota Euryarchaeota Nanoarcheota Alphaproteobacteria Betaproteobacteria Gammaproteobacteria Deltaproteobacteria Epsilonproteobacteria Cyanobacteria Actinobacteridae Firmicutes Spirochaetes others Protist Microsporidia Fungi Metazoa Plantae
information on phylogenetic profile
locus tag mg1655b2684
locus tag w3110JW2659
gene name k12mprA
locus namemprA
synonyms of locus nameemrA, emrR

scop id46785
superfamilyWinged helix
pfam idPF01047
pfam domainMarR family
TIGRFAMno information

swissprot nameMPRA_ECOLI
descriptionTranscriptional repressor mprA (Protein emrR).
seq length176
fastaseq

go idGO:0005737; GO:0016564; GO:0006350; GO:0042493
go termcytoplasm; transcriptional repressor activity; transcription; response to drug

gene product descriptionDNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux
comment gene product description
evidenceE
context
gene product descRegulator
cell locationCytoplasmic
featuresCDS

functional category codeK
functional categoryTranscription

reference #1mprA, an Escherichia coli gene that reduces growth-phase-dependent synthesis of microcins B17 and C7 and blocks osmoinduction of proU when cloned on a high-copy-number plasmid.

del Castillo I., Gómez J., Moreno F. (J Bacteriol. 1990 Jan; 172(1):437-45)
reference #2Nucleotide sequence of the Escherichia coli regulatory gene mprA and construction and characterization of mprA-deficient mutants.

del Castillo I., González-Pastor J., San Millán J., Moreno F. (J Bacteriol. 1991 Jun; 173(12):3924-9)
reference #3Genetic analysis of the stationary phase-induced mcb operon promoter in Escherichia coli.

Mao W., Siegele D. (Mol Microbiol. 1998 Jan; 27(2):415-24)
reference #4Purification and ligand binding of EmrR, a regulator of a multidrug transporter.

Brooun A., Tomashek J., Lewis K. (J Bacteriol. 1999 Aug; 181(16):5131-3)
reference #5Emr, an Escherichia coli locus for multidrug resistance.

Lomovskaya O., Lewis K. (Proc Natl Acad Sci U S A. 1992 Oct 1; 89(19):8938-42)
reference #6Nucleotide sequence of the Escherichia coli regulatory gene mprA and construction and characterization of mprA-deficient mutants.

del Castillo I., González-Pastor J., San Millán J., Moreno F. (J Bacteriol. 1991 Jun; 173(12):3924-9)
reference #7EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB.

Lomovskaya O., Lewis K., Matin A. (J Bacteriol. 1995 May; 177(9):2328-34)

phylogenetic profile
 
1 1 55 1 1 1 1 1 1 1 53 51 50 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 60 53 53 51 1 1 54 1 1 54 1
1 1 1 1 1 1 1 51 1 61 61 61 51 50 128 1 1 1 53 1
52 1 1 1 1 1 1 57 1 1 1 1 1 1 1 1 69 70 70 1
58 57 1 53 1 55 1 76 1 1 1 1 1 1 1 1 1 1 1 1
1 1 57 1 1 1 1 1 1 50 50 51 1 1 1 1 1 1 1 1
1 50 1 1 1 1 1 239 353 351 353 1 1 57 1 1 1 238 50 1
1 331 331 331 61 278 352 1 57 1 1 81 83 61 61 267 267 267 1 1
1 1 1 1 1 1 1 1 57 1 1 1 1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1