Gene Details


gene name: malY


locus tag k12ECK1617 Crenarchaeota Euryarchaeota Nanoarcheota Alphaproteobacteria Betaproteobacteria Gammaproteobacteria Deltaproteobacteria Epsilonproteobacteria Cyanobacteria Actinobacteridae Firmicutes Spirochaetes others Protist Microsporidia Fungi Metazoa Plantae
information on phylogenetic profile
locus tag mg1655b1622
locus tag w3110JW1614
gene name k12malY
locus namemalY
synonyms of locus name

scop id53383
superfamilyPLP-dependent transferases
pfam idPF00155
pfam domainAminotransferase class I and II
TIGRFAMno information

swissprot nameMALY_ECOLI
descriptionProtein malY [Includes: Cystathionine beta-lyase (EC 4.4.1.8) (CBL)|(Beta-cystathionase) (Cysteine lyase); Maltose regulon modulator].
seq length390
fastaseq

go idGO:0005737; GO:0016052; GO:0016052
go termcytoplasm; carbohydrate catabolism; carb catab

gene product descriptionbifunctional beta-cystathionase, PLP-dependent and regulator of maltose regulon
comment gene product description
evidenceE
context
gene product descEnzyme
cell locationCytoplasmic
featuresCDS

functional category codeE
functional categoryAmino acid transport and metabolism

reference #1X-ray structure of MalY from Escherichia coli: a pyridoxal 5'-phosphate-dependent enzyme acting as a modulator in mal gene expression.

Clausen T., Schlegel A., Peist R., Schneider E., Steegborn C., Chang Y., Haase A., Bourenkov G., Bartunik H., Boos W. (EMBO J. 2000 Mar 1; 19(5):831-42)
reference #2MalY of Escherichia coli is an enzyme with the activity of a beta C-S lyase (cystathionase).

Zdych E., Peist R., Reidl J., Boos W. (J Bacteriol. 1995 Sep; 177(17):5035-9)
reference #3The malX malY operon of Escherichia coli encodes a novel enzyme II of the phosphotransferase system recognizing glucose and maltose and an enzyme abolishing the endogenous induction of the maltose system.

Reidl J., Boos W. (J Bacteriol. 1991 Aug; 173(15):4862-76)

phylogenetic profile
 
72 61 59 62 68 70 63 72 53 1 67 65 1 71 76 70 53 53 1 167
131 120 117 1 162 160 162 162 62 1 76 468 56 54 54 67 1 1 59 52
52 57 73 57 1 1 1 97 62 69 66 63 57 58 67 62 63 217 152 82
76 57 71 61 68 66 72 67 1 221 57 80 78 70 67 192 209 211 214 240
253 246 263 72 248 337 210 322 194 233 230 229 149 229 1 1 1 1 130 1
1 1 236 1 76 76 76 76 76 187 191 187 196 197 62 62 62 62 62 80
1 65 1 1 1 1 69 62 798 803 803 1 64 63 62 211 54 261 80 83
63 209 219 209 66 801 801 52 50 51 1 58 59 1 51 240 239 260 73 231
238 56 56 56 1 51 1 67 164 204 1 1 1 52 134 1 67 189 1 67
60 60 80 61 64 55 51 58 57 63 62 57 53 61 1 57 73 1 1