gene name: ispH
| locus tag k12 | ECK0030 | information on phylogenetic profile |
|---|---|---|
| locus tag mg1655 | b0029 | |
| locus tag w3110 | JW0027 | |
| gene name k12 | ispH | |
| locus name | ispH | |
| synonyms of locus name | lytB, yaaE |
| SCOP | no information |
|---|---|
| pfam id | PF02401 |
| pfam domain | LytB protein |
| tigrfam id | TIGR00216 |
| name | ispH_lytB |
| function | 4-hydroxy-3-methylbut-2-enyl dip |
| swissprot name | ISPH_ECOLI |
|---|---|
| description | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2). |
| seq length | 316 |
| fastaseq |
| go id | GO:0005737; GO:0042493 |
|---|---|
| go term | cytoplasm; response to drug |
| gene product description | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein |
|---|---|
| comment gene product description | |
| evidence | E |
| context | |
| gene product desc | Carrier |
| cell location | Cytoplasmic |
| features | CDS |
| functional category code | M; I |
|---|---|
| functional category | Cell wall/membrane/envelope biogenesis ; Lipid transport and metabolism |
| reference #1 | Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase. Adam P., Hecht S., Eisenreich W., Kaiser J., Grawert T., Arigoni D., Bacher A., Rohdich F. (Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12108-13) |
|---|---|
| reference #2 | Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein. Wolff M., Seemann M., Tse Sum Bui B., Frapart Y., Tritsch D., Garcia Estrabot A., Rodríguez-Concepción M., Boronat A., Marquet A., Rohmer M. (FEBS Lett. 2003 Apr 24; 541(1-3):115-20) |
| reference #3 | LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. Altincicek B., Kollas A., Eberl M., Wiesner J., Sanderbrand S., Hintz M., Beck E., Jomaa H. (FEBS Lett. 2001 Jun 15; 499(1-2):37-40) |
| reference #4 | The lytB gene of Escherichia coli is essential and specifies a product needed for isoprenoid biosynthesis. McAteer S., Coulson A., McLennan N., Masters M. (J Bacteriol. 2001 Dec; 183(24):7403-7) |
| reference #5 | Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. Rohdich F., Hecht S., Gärtner K., Adam P., Krieger C., Amslinger S., Arigoni D., Bacher A., Eisenreich W. (Proc Natl Acad Sci U S A. 2002 Feb 5; 99(3):1158-63) |
| reference #6 | Identification of the Escherichia coli lytB gene, which is involved in penicillin tolerance and control of the stringent response. Gustafson C., Kaul S., Ishiguro E. (J Bacteriol. 1993 Feb; 175(4):1203-5) |
| reference #7 | Occurrence of homologs of the Escherichia coli lytB gene in gram-negative bacterial species. Potter S., Yang X., Boulanger M., Ishiguro E. (J Bacteriol. 1998 Apr; 180(7):1959-61) |
| phylogenetic profile |
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