gene name: hepA
| locus tag k12 | ECK0060 | information on phylogenetic profile |
|---|---|---|
| locus tag mg1655 | b0059 | |
| locus tag w3110 | JW0058 | |
| gene name k12 | hepA | |
| locus name | hepA | |
| synonyms of locus name | rapA, yabA |
| scop id | 52540 |
|---|---|
| superfamily | P-loop containing nucleotide triphosphate hydrolases |
| pfam id | PF04851; PF00271; PF00176 |
| pfam domain | Type III restriction enzyme, res subunit; Helicase conserved C-terminal domain; SNF2 family N-terminal domain |
| TIGRFAM | no information |
| swissprot name | RAPA_ECOLI |
|---|---|
| description | RNA polymerase-associated protein rapA (EC 3.6.1.-) (ATP-dependent|helicase hepA). |
| seq length | 967 |
| fastaseq |
| go id | GO:0009451 |
|---|---|
| go term | RNA modification |
| gene product description | RNA polymerase-associated helicase protein (ATPase and RNA polymerase recycling factor) |
|---|---|
| comment gene product description | putative helicase protein A |
| evidence | E |
| context | |
| gene product desc | Factor |
| cell location | Cytoplasmic |
| features | CDS |
| functional category code | K; L |
|---|---|
| functional category | Transcription ; Replication, recombination and repair |
| reference #1 | RapA, a bacterial homolog of SWI2/SNF2, stimulates RNA polymerase recycling in transcription. Sukhodolets M., Cabrera J., Zhi H., Jin D. (Genes Dev. 2001 Dec 15; 15(24):3330-41) |
|---|---|
| reference #2 | Interaction between RNA polymerase and RapA, a bacterial homolog of the SWI/SNF protein family. Sukhodolets M., Jin D. (J Biol Chem. 2000 Jul 21; 275(29):22090-7) |
| reference #3 | Isolation of DNA damage-inducible promoters in Escherichia coli: regulation of polB (dinA), dinG, and dinH by LexA repressor. Lewis L., Jenkins M., Mount D. (J Bacteriol. 1992 May; 174(10):3377-85) |
| reference #4 | Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region. Yura T., Mori H., Nagai H., Nagata T., Ishihama A., Fujita N., Isono K., Mizobuchi K., Nakata A. (Nucleic Acids Res. 1992 Jul 11; 20(13):3305-8) |
| reference #5 | Characterization of monoclonal antibodies against Escherichia coli core RNA polymerase. Rouby J., Pugniere M., Mani J., Granier C., Monmouton P., Theulier Saint Germain S., Leonetti J. (Biochem J. 2002 Jan 15; 361(Pt 2):347-54) |
| reference #6 | Growth phase and growth rate regulation of the rapA gene, encoding the RNA polymerase-associated protein RapA in Escherichia coli. Cabrera J., Jin D. (J Bacteriol. 2001 Oct; 183(20):6126-34) |
| reference #7 | Escherichia coli DNA polymerase II is homologous to alpha-like DNA polymerases. Iwasaki H., Ishino Y., Toh H., Nakata A., Shinagawa H. (Mol Gen Genet. 1991 Apr; 226(1-2):24-33) |
| reference #8 | An expanding family of helicases within the 'DEAD/H' superfamily. Bork P., Koonin E. (Nucleic Acids Res. 1993 Feb 11; 21(3):751-2) |
| reference #9 | RapA, a novel RNA polymerase-associated protein, is a bacterial homolog of SWI2/SNF2. Sukhodolets M., Jin D. (J Biol Chem. 1998 Mar 20; 273(12):7018-23) |
| reference #10 | Disruption of Escherichia coli hepA, an RNA polymerase-associated protein, causes UV sensitivity. Muzzin O., Campbell E., Xia L., Severinova E., Darst S., Severinov K. (J Biol Chem. 1998 Jun 12; 273(24):15157-61) |
| phylogenetic profile |
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