Gene Details


gene name: gadB


locus tag k12ECK1487 Crenarchaeota Euryarchaeota Nanoarcheota Alphaproteobacteria Betaproteobacteria Gammaproteobacteria Deltaproteobacteria Epsilonproteobacteria Cyanobacteria Actinobacteridae Firmicutes Spirochaetes others Protist Microsporidia Fungi Metazoa Plantae
information on phylogenetic profile
locus tag mg1655b1493
locus tag w3110JW1488
gene name k12gadB
locus namegadB
synonyms of locus name

scop id53383
superfamilyPLP-dependent transferases
pfam idPF00282
pfam domainPyridoxal-dependent decarboxylase conse
tigrfam idTIGR01788
nameGlu-decarb-GAD
functionglutamate decarboxylas

swissprot nameDCEB_ECOLI
descriptionGlutamate decarboxylase beta (EC 4.1.1.15) (GAD-beta).
seq length466
fastaseq

go idGO:0005737; GO:0009063; GO:0009063; GO:0006520; GO:0009063
go termcytoplasm; aa catab; amino acid catabolism; amino acid metabolism; aa catabolism

gene product descriptionglutamate decarboxylase B, PLP-dependent
comment gene product description
evidenceE
context
gene product descEnzyme
cell locationCytoplasmic
featuresCDS

functional category codeE
functional categoryAmino acid transport and metabolism

reference #1Crystal structure and functional analysis of Escherichia coli glutamate decarboxylase.

Capitani G., De Biase D., Aurizi C., Gut H., Bossa F., Grütter M. (EMBO J. 2003 Aug 15; 22(16):4027-37)
reference #2The amino acid sequence of glutamate decarboxylase from Escherichia coli. Evolutionary relationship between mammalian and bacterial enzymes.

Maras B., Sweeney G., Barra D., Bossa F., John R. (Eur J Biochem. 1992 Feb 15; 204(1):93-8)
reference #3Escherichia coli has two homologous glutamate decarboxylase genes that map to distinct loci.

Smith D., Kassam T., Singh B., Elliott J. (J Bacteriol. 1992 Sep; 174(18):5820-6)
reference #4Ornithine and glutamate decarboxylases catalyse an oxidative deamination of their alpha-methyl substrates.

Bertoldi M., Carbone V., Borri Voltattorni C.
reference #5Function of the Escherichia coli nucleoid protein, H-NS: molecular analysis of a subset of proteins whose expression is enhanced in a hns deletion mutant.

Yoshida T., Ueguchi C., Yamada H., Mizuno T. (Mol Gen Genet. 1993 Feb; 237(1-2):113-22)

phylogenetic profile
 
83 1 1 1 83 72 79 57 60 97 336 78 92 90 88 90 1 1 1 1
1 1 1 1 414 1 414 414 436 1 409 417 77 1 1 1 1 1 1 496
1 1 60 1 1 1 1 1 1 330 1 1 1 98 1 1 1 1 1 1
1 1 517 1 1 464 1 1 550 1 53 1 1 1 1 1 1 1 445 1
1 1 1 427 1 1 1 390 400 414 415 411 415 414 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 966 969 969 1 52 52 1 1 1 1 1 1
1 1 1 1 407 969 969 1 1 1 1 1 1 1 1 1 1 1 1 389
387 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
1 279 275 271 382 281 1 313 85 102 95 91 78 76 1 398 375 1 1