Gene Details


gene name: dnaE


locus tag k12ECK0183 Crenarchaeota Euryarchaeota Nanoarcheota Alphaproteobacteria Betaproteobacteria Gammaproteobacteria Deltaproteobacteria Epsilonproteobacteria Cyanobacteria Actinobacteridae Firmicutes Spirochaetes others Protist Microsporidia Fungi Metazoa Plantae
information on phylogenetic profile
locus tag mg1655b0184
locus tag w3110JW0179
gene name k12dnaE
locus namednaE
synonyms of locus namepolC, sdgC

scop id50249
superfamilyNucleic acid-binding proteins
pfam idPF01336; PF07733; PF02811; PF02231
pfam domainOB-fold nucleic acid binding domain; Bacterial DNA polymerase III alpha subunit; PHP domain C-terminal region; PHP domain N-terminal region
tigrfam idTIGR00594
namepolc
functionDNA polymerase III, alpha subunit

swissprot nameDPO3A_ECOLI
descriptionDNA polymerase III subunit alpha (EC 2.7.7.7).
seq length1160
fastaseq

go idGO:0005737; GO:0006261
go termcytoplasm; DNA dependent DNA replication

gene product descriptionDNA polymerase III alpha subunit
comment gene product description
evidenceE
context
gene product descEnzyme
cell locationCytoplasmic
featuresCDS

functional category codeL
functional categoryReplication, recombination and repair

reference #1Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme.

Stukenberg P., Studwell-Vaughan P., O'Donnell M. (J Biol Chem. 1991 Jun 15; 266(17):11328-34)
reference #2Fluorescence energy transfer between the primer and the beta subunit of the DNA polymerase III holoenzyme.

Griep M., McHenry C. (J Biol Chem. 1992 Feb 15; 267(5):3052-9)
reference #3Coordinated leading- and lagging-strand synthesis at the Escherichia coli DNA replication fork. IV. Reconstitution of an asymmetric, dimeric DNA polymerase III holoenzyme.

Wu C., Zechner E., Hughes A., Franden M., McHenry C., Marians K. (J Biol Chem. 1992 Feb 25; 267(6):4064-73)
reference #4Accessory protein function in the DNA polymerase III holoenzyme from E. coli.

O'Donnell M. (Bioessays. 1992 Feb; 14(2):105-11)
reference #5Sequence analysis of the Escherichia coli dnaE gene.

Tomasiewicz H., McHenry C. (J Bacteriol. 1987 Dec; 169(12):5735-44)
reference #6Growth rate regulation of Escherichia coli acetyl coenzyme A carboxylase, which catalyzes the first committed step of lipid biosynthesis.

Li S., Cronan J. (J Bacteriol. 1993 Jan; 175(2):332-40)
reference #7Antimutator mutations in the alpha subunit of Escherichia coli DNA polymerase III: identification of the responsible mutations and alignment with other DNA polymerases.

Fijalkowska I., Schaaper R. (Genetics. 1993 Aug; 134(4):1039-44)

phylogenetic profile
 
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 666
591 615 603 712 661 651 661 661 670 599 681 664 756 632 633 808 779 781 793 804
804 774 794 781 661 642 644 807 712 1054 1054 1054 1029 1033 998 993 992 981 1029 533
728 694 715 716 713 537 553 778 808 880 898 733 701 711 712 780 652 659 655 647
675 692 729 756 702 528 517 550 399 617 618 617 617 614 331 277 325 349 347 407
308 338 603 215 513 509 513 509 513 372 372 406 416 414 376 377 374 376 376 762
391 1017 1268 1120 1277 1346 1183 2039 2276 2278 2278 1687 1247 1249 1713 1241 1670 2001 1303 1293
1283 2222 2222 2222 1684 2276 2276 1783 1803 1794 1181 1011 1004 995 1003 2059 2059 2061 708 613
618 679 679 679 673 663 677 667 587 665 731 682 601 234 502 754 721 768 691 721
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1