Gene Details


gene name: cysI


locus tag k12ECK2758 Crenarchaeota Euryarchaeota Nanoarcheota Alphaproteobacteria Betaproteobacteria Gammaproteobacteria Deltaproteobacteria Epsilonproteobacteria Cyanobacteria Actinobacteridae Firmicutes Spirochaetes others Protist Microsporidia Fungi Metazoa Plantae
information on phylogenetic profile
locus tag mg1655b2763
locus tag w3110JW2733
gene name k12cysI
locus namecysI
synonyms of locus namecysQ

scop id56014; 55124
superfamilySulfite reductase hemoprotein (SiRHP), domains 2 and 4; Sulfite reductase, domains 1 and 3
pfam idPF01077; PF03460
pfam domainNitrite and sulphite reductase 4Fe-4S do; Nitrite/Sulfite reductase ferredoxin-like
tigrfam idTIGR02041
nameCysI
functionsulfite reductase (NADPH) hemoprotein,

swissprot nameCYSI_ECOLI
descriptionSulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2)|(SIR-HP) (SIRHP).
seq length569
fastaseq

go idGO:0006790
go termsulfur metabolism

gene product descriptionsulfite reductase, beta subunit, NAD(P)-binding, heme-binding
comment gene product descriptionmisannotated in some databases as alpha subunit
evidenceE
context
gene product descEnzyme
cell locationCytoplasmic
featuresCDS

functional category codeP
functional categoryInorganic ion transport and metabolism

reference #1Mössbauer spectroscopic studies of Escherichia coli sulfite reductase. Evidence for coupling between the siroheme and Fe4S4 cluster prosthetic groups.

Christner J., Münck E., Janick P., Siegel L. (J Biol Chem. 1981 Mar 10; 256(5):2098-101)
reference #2Escherichia coli sulfite reductase hemoprotein subunit. Prosthetic groups, catalytic parameters, and ligand complexes.

Siegel L., Rueger D., Barber M., Krueger R., Orme-Johnson N., Orme-Johnson W. (J Biol Chem. 1982 Jun 10; 257(11):6343-50)
reference #3Cloning of the 3'-phosphoadenylyl sulfate reductase and sulfite reductase genes from Escherichia coli K-12.

Li C., Peck H., Przybyla A. (Gene. 1987; 53(2-3):227-34)
reference #4Characterization of the cysJIH regions of Salmonella typhimurium and Escherichia coli B. DNA sequences of cysI and cysH and a model for the siroheme-Fe4S4 active center of sulfite reductase hemoprotein based on amino acid homology with spinach nitrite reductase.

Ostrowski J., Wu J., Rueger D., Miller B., Siegel L., Kredich N. (J Biol Chem. 1989 Sep 15; 264(26):15726-37)
reference #5Characterisation of the gene cysH and of its product phospho-adenylylsulphate reductase from Escherichia coli.

Krone F., Westphal G., Schwenn J. (Mol Gen Genet. 1991 Feb; 225(2):314-9)
reference #6Characterization of the cysJIH regions of Salmonella typhimurium and Escherichia coli B. DNA sequences of cysI and cysH and a model for the siroheme-Fe4S4 active center of sulfite reductase hemoprotein based on amino acid homology with spinach nitrite reductase.

Ostrowski J., Wu J., Rueger D., Miller B., Siegel L., Kredich N. (J Biol Chem. 1989 Sep 15; 264(26):15726-37)
reference #7Sulfite reductase structure at 1.6 A: evolution and catalysis for reduction of inorganic anions.

Crane B., Siegel L., Getzoff E. (Science. 1995 Oct 6; 270(5233):59-67)
reference #8Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.

Link A., Robison K., Church G. (Electrophoresis. 1997 Aug; 18(8):1259-313)
reference #9Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: heme activation via reduction-gated exogenous ligand exchange.

Crane B., Siegel L., Getzoff E. (Biochemistry. 1997 Oct 7; 36(40):12101-19)

phylogenetic profile
 
1 96 157 172 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
1 94 95 1 97 1 97 97 107 1 120 119 1 1 1 1 1 1 72 1
1 81 64 103 1 1 1 61 1 1 1 1 62 62 1 768 770 490 53 336
337 265 262 260 255 305 333 1 1 1 1 1 1 1 1 1 98 101 93 574
567 565 1 79 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
1 1 529 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
1 1 660 1 1 744 1 941 1089 1090 1090 1 1 1 756 78 1 906 1 55
1 1036 1046 1036 642 1089 1089 799 800 805 1 512 504 497 492 922 922 925 78 1
1 1 1 1 1 1 1 1 104 1 1 333 1 1 79 1 335 1 1 296
444 464 459 261 478 450 421 438 1 1 1 1 1 1 1 309 282 1 1