gene name: araC
| locus tag k12 | ECK0065 | information on phylogenetic profile |
|---|---|---|
| locus tag mg1655 | b0064 | |
| locus tag w3110 | JW0063 | |
| gene name k12 | araC | |
| locus name | araC | |
| synonyms of locus name |
| scop id | 46689; 51215 |
|---|---|
| superfamily | Homeodomain-like; Regulatory protein AraC |
| pfam id | PF02311; PF00165 |
| pfam domain | AraC-like ligand binding domain; Bacterial regulatory helix-turn-helix prot, AraC fam |
| TIGRFAM | no information |
| swissprot name | ARAC_ECOLI |
|---|---|
| description | Arabinose operon regulatory protein. |
| seq length | 292 |
| fastaseq |
| go id | GO:0005737; GO:0016563; GO:0016564; GO:0006350; GO:0016052; GO:0016052 |
|---|---|
| go term | cytoplasm; transcriptional activator activity; transcriptional repressor activity; transcription; carbohydrate catabolism; carb catab |
| gene product description | DNA-binding transcriptional dual regulator |
|---|---|
| comment gene product description | |
| evidence | E |
| context | |
| gene product desc | Regulator |
| cell location | Cytoplasmic |
| features | CDS |
| functional category code | K |
|---|---|
| functional category | Transcription |
| reference #1 | Arabinose-induced binding of AraC protein to araI2 activates the araBAD operon promoter. Lee N., Francklyn C., Hamilton E. (Proc Natl Acad Sci U S A. 1987 Dec; 84(24):8814-8) |
|---|---|
| reference #2 | Activation of ara operons by a truncated AraC protein does not require inducer. Menon K., Lee N. (Proc Natl Acad Sci U S A. 1990 May; 87(10):3708-12) |
| reference #3 | AraC-DNA looping: orientation and distance-dependent loop breaking by the cyclic AMP receptor protein. Lobell R., Schleif R. (J Mol Biol. 1991 Mar 5; 218(1):45-54) |
| reference #4 | The araC regulatory gene mRNA contains a leader sequence. Cass L., Horwitz A., Miyada C., Greenfield L., Wilcox G. (Mol Gen Genet. 1980; 180(1):219-26) |
| reference #5 | Is the amino acid but not the nucleotide sequence of the Escherichia coli araC gene conserved? Stoner C., Schleif R. (J Mol Biol. 1982 Feb 5; 154(4):649-52) |
| reference #6 | DNA sequence of the araC regulatory gene from Escherichia coli B/r. Miyada C., Horwitz A., Cass L., Timko J., Wilcox G. (Nucleic Acids Res. 1980 Nov 25; 8(22):5267-74) |
| reference #7 | The araC gene of Escherichia coli: transcriptional and translational start-points and complete nucleotide sequence. Wallace R., Lee N., Fowler A. (Gene. 1980 Dec; 12(3-4):179-90) |
| reference #8 | Structural basis for ligand-regulated oligomerization of AraC. Soisson S., MacDougall-Shackleton B., Schleif R., Wolberger C. (Science. 1997 Apr 18; 276(5311):421-5) |
| reference #9 | The 1.6 A crystal structure of the AraC sugar-binding and dimerization domain complexed with D-fucose. Soisson S., MacDougall-Shackleton B., Schleif R., Wolberger C. (J Mol Biol. 1997 Oct 17; 273(1):226-37) |
| phylogenetic profile |
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