Gene Details


gene name: apaH


locus tag k12ECK0050 Crenarchaeota Euryarchaeota Nanoarcheota Alphaproteobacteria Betaproteobacteria Gammaproteobacteria Deltaproteobacteria Epsilonproteobacteria Cyanobacteria Actinobacteridae Firmicutes Spirochaetes others Protist Microsporidia Fungi Metazoa Plantae
information on phylogenetic profile
locus tag mg1655b0049
locus tag w3110JW0048
gene name k12apaH
locus nameapaH
synonyms of locus namecfcB

scop id56300
superfamilyMetallo-dependent phosphatases
pfam idPF00149
pfam domainCalcineurin-like phosphoesterase
tigrfam idTIGR00668
nameapaH
functionbis(5'-nucleosyl)-tetraphosphatase (sy

swissprot nameAPAH_ECOLI
descriptionBis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC 3.6.1.41)|(Diadenosine tetraphosphatase) (Ap4A hydrolase) (Diadenosine 5',5'''-|P1,P4-tetraphosphate pyrophosphohydrolase).
seq length280
fastaseq

go idGO:0005737; GO:0015949; GO:0015949
go termcytoplasm; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide interconversion

gene product descriptiondiadenosine tetraphosphatase
comment gene product description
evidenceE
context
gene product descEnzyme
cell locationCytoplasmic
featuresCDS

functional category codeT
functional categorySignal transduction mechanisms

reference #1An apaH mutation causes AppppA to accumulate and affects motility and catabolite repression in Escherichia coli.

Farr S., Arnosti D., Chamberlin M., Ames B. (Proc Natl Acad Sci U S A. 1989 Jul; 86(13):5010-4)
reference #2Overlap between pdxA and ksgA in the complex pdxA-ksgA-apaG-apaH operon of Escherichia coli K-12.

Roa B., Connolly D., Winkler M. (J Bacteriol. 1989 Sep; 171(9):4767-77)
reference #3AppppA binds to several proteins in Escherichia coli, including the heat shock and oxidative stress proteins DnaK, GroEL, E89, C45 and C40.

Johnstone D., Farr S. (EMBO J. 1991 Dec; 10(12):3897-904)
reference #4The gene for Escherichia coli diadenosine tetraphosphatase is located immediately clockwise to folA and forms an operon with ksgA.

Blanchin-Roland S., Blanquet S., Schmitter J., Fayat G. (Mol Gen Genet. 1986 Dec; 205(3):515-22)
reference #5Catabolism of diadenosine 5',5"'-P1,P4-tetraphosphate in procaryotes. Purification and properties of diadenosine 5',5"'-P1,P4-tetraphosphate (symmetrical) pyrophosphohydrolase from Escherichia coli K12.

Guranowski A., Jakubowski H., Holler E. (J Biol Chem. 1983 Dec 25; 258(24):14784-9)

phylogenetic profile
 
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 1 1 54 51 1 1 1 1 1 1 1
1 1 1 1 1 1 1 50 1 206 206 206 219 218 244 206 235 246 192 58
1 1 1 1 1 1 71 1 1 1 1 1 1 1 1 1 1 1 1 55
69 60 58 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
1 214 244 287 292 295 232 444 580 581 581 315 254 256 300 255 305 429 272 265
256 548 548 548 260 586 586 306 310 300 257 217 217 214 216 464 464 465 1 1
1 1 1 1 1 1 1 1 60 1 1 1 1 50 1 1 1 1 1 1
1 54 56 1 50 57 1 1 1 52 50 1 1 1 1 1 63 1 1